Seattle, WA: IHME, University of Washington, 2021. Institute for Health Metrics and Evaluation (IHME).Currently, there are no approved treatments which alter the course of osteoarthritis at Biosplice Therapeutics, we hope to change this with lorecivivint. 6 Palliative therapeutics compromise on efficacy, safety or durability. 6 Characteristics of the disease include: degradation of tendons, ligaments and cartilage (the cushioning tissue between joints), bony changes of the joints, and inflammation of the joint lining (called the synovium). While osteoarthritis is frequently described as a “wear and tear” disease, we understand it now as a disease of the whole joint, involving the cartilage, joint lining, ligaments, and bone. In addition, many people with osteoarthritis are also diagnosed with other chronic conditions, such as heart disease, diabetes, and obesity these comorbidities add to the burden that osteoarthritis sufferers manage.
Regardless of where patients are in their osteoarthritis progression, their lives are impacted when everyday activities like walking a few blocks or going up and down stairs cause too much pain. People living with osteoarthritis may experience a variety of symptoms for some, pain is mild and occurs occasionally, while for others pain is severe and chronic. Those who live with osteoarthritis experience pain, stiffness, and swelling, which limits their function and mobility these symptoms often impact osteoarthritis suffers in their daily lives. 5 Osteoarthritis may affect the knees, hips, hands, spine, or feet 6 current estimates indicate that there are 24.7 million, 1 in 10 U.S. adults suffering with osteoarthritis are of working age (20-64 years). 3,4 While often considered a disease of old age, an estimated 11.6 million U.S. 2 Osteoarthritis is the most prevalent joint disease and a leading source of chronic pain and disability in the United States. adults 1 and 527.8 million adults globally. Osteoarthritis, the most common form of arthritis, is a serious chronic disease that affects an estimated 51.9 million U.S.
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